Complex Measurement Systems in Medicine: from Synchronized Monotask Measuring Instruments to Cyber-Physical Systems

Е.L. Wasserman, N.К. Кartashev, S.B. Roudnitsky, О.V. Zhvalevsky


Design problems of flexible computer systems for physiological researches are discussed. The widespread case of employing of commercial medical devices as parts of the resulting computer system is analyzed. To overcome most of the arising difficulties, we propose using of the universal synchronizing device and the modular script-based software. The prospects of such computer systems are outlined as a development into cyberphysical systems with on-demand plugging in of required hardware modules.


cyber-physical systems; integration; aggregation; medical systems; synchronization


J. Gotman and F. Pittau, “Combining EEG and fMRI in the study of epileptic discharges,” Epilepsia, vol. 52, suppl. 4, pp. 38-42, Jul. 2011. DOI: 10.1111/j.1528-1167.2011.03151.x.

S.F. Storti, E. Formaggio, E. Franchini, L.G. Bongiovanni, R. Cerini, A. Fiaschi, C.M. Michel, and P. Manganotti, “A multimodal imaging approach to the evaluation of post-traumatic epilepsy,” MAGMA, vol. 25(5), pp. 345-360. Oct. 2012. DOI: 10.1007/s10334-012-0316-9

K.K. Venkatasubramanian, E.Y. Vasserman, V. Sfyrla, O. Sokolsky, and I. Lee, “Requirement engineering for functional alarm system for interoperable medical devices”, In Proceedings of the 34th International Conference on Computer Safety, Reliability and Security (SAFECOMP 2015), The Delft, The Netherlands, pp. 252-266, Sept. 2015. DOI: 10.1007/978-3-319-24255-2_19

R. Rajkumar, D. Niz, and M. Klein, Cyber-Physical Systems. Boston, MA: Addison-Wesley, 2016.

I. Lee, A. Ayoub, S. Chen, B. Kim, A. King, A. Roederer, and O. Sokolsky, “Medical cyber-physical systems,” in Cyber-Physical Systems, R. Rajkumar, D. Niz, and M. Klein, Boston, MA : Addison- Wesley, 2016, pp. 3–60.

I. Lee, O. Sokolsky, S. Chen, J. Hatcliff, E. Jee, B.G. Kim, A. King, M. Mullen-Fortino, S. Park, A. Roederer, and K. Venkatasubramanian, “Challenges and research directions in medical cyber-physical systems,” Proceedings of the IEEE, vol. 100(1), pp. 75-90, Jan. 2012. DOI: 10.1109/JPROC.2011.2165270

M. Pajic, R. Mangharam, O. Sokolsky, D. Arney, J.M. Goldman, and I. Lee, “Model-driven safety analysis of closed-loop medical systems,” IEEE Transactions on Industrial Informatics, vol. 10(1), pp. 3-16, Oct. 2012. DOI: 10.1109/TII.2012.2226594

J. Weimer, R. Ivanov, A. Roederer, S. Chen, and I. Lee, “Parameterinvariant design of medical alarms,” IEEE Design and Test, vol. 32(5), pp. 9-16, Oct. 2015. DOI: 10.1109/MDAT.2015.2451083

J. Weimer, O. Sokolsky, and I. Lee, “Robust medical monitor design,” International Conference on Healthcare Informatics (ICHI), Dallas, TX, pp. 445-445, Oct. 2015. DOI: 10.1109/ICHI.2015.63

S. Chen, O. Sokolsky, J. Weimer, and I. Lee, “Data-driven adaptive safety monitoring using virtual subjects in medical cyber-physical systems: a glucose control case study,” Journal of Computer Science and Engineering, vol. 10(3), pp. 75-84, sept. 2016. DOI: 10.5626/JCSE.2016.10.3.75

O. Kocabas, T. Soyata, and M.K. Aktas, “Emerging security mechanisms for medical cyber physical systems,” IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 13(3), pp. 401-416, May-Jun. 2016. DOI: 10.1109/TCBB.2016.2520933

J. Jezewski, A. Pawlak, J. Wróbel, K. Horoba, and P. Penkala, “Towards a medical cyber-physical system for home telecare of high-risk pregnancy,” IFAC-PapersOnLine, vol. 48(4), pp. 466-473, Dec. 2015. DOI: 10.1016/j.ifacol.2015.07.079

I. Lee, and O. Sokolsky, “Medical Cyber Physical Systems,” 47th Design Automation Conference (DAC '10), pp. 743-748, June 2010. DOI: 10.1145/1837274.1837463

E. Bartocci, S. Gao, and S.A. Smolka, “Medical cyber-physical systems,” in Leveraging Applications of Formal Methods, Verification and Validation. Specialized Techniques and Applications. ISoLA 2014. Lecture Notes in Computer Science, T. Margaria and B. Steffen, Eds. Berlin, Heidelberg: Springer, vol. 8803, pp. 353-355, Oct. 2014. DOI: 10.1007/978-3-662-45231-8_25

L.C. Silva, M. Perkusich, H.O. Almeida, A. Perkusich, M.A. Lima, and K.C. Gorgônio, “A baseline patient model to support testing of medical cyber-physical systems,” Studies in Health Technology and Informatics, vol. 216, pp. 549-553, Aug. 2015. DOI:10.3233/978-1-61499-564-7-549

L.C. Silva, H.O. Almeida, A. Perkusich, and M. Perkusich, “A modelbased approach to support validation of medical cyber-physical systems,” Sensors, vol. 15(11), pp. 27625–27670, Oct. 2015. DOI: 10.3390/s151127625

S.B. Roudnitsky, E.L. Wasserman, N.K. Kartashev, and O.V. Zhvalevsky, “Measurement integration in physiological studies: computer system based on external synchronizer,” (in Russian), Biotekhnosfera, No. 3-4. pp. 72–77, 2012.

E.L. Wasserman, N.K. Kartashev, O.V. Zhvalevsky, and S.B. Roudnitsky, “Flexible architecture of hardware-software complexes for physiological researches,” (in Russian), Izvestiya Vysshikh Uchebnykh Zavedenii. Priborostroenie, vol. 59(11), pp. 952-958, Nov. 2016. DOI:10.17586/0021-3454-2016-59-11-952-958952

J. Gotman, E. Kobayashi, A.P. Bagshaw, C.G. Bénar, and F. Dubeau, “Combining EEG and fMRI: a multimodal tool for epilepsy research,” Journal of Magnetic Resonance Imaging, vol. 23(6), pp. 906-920, Jun. 2006. DOI: 10.1002/jmri.20577

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